the immunological responses to various cell wall fractions of pasteurella multocida in chicken

The Immunological Responses to Various Cell Wall Fractions of Pasteurella multocida in Chicken

Pasteurella multocida chest wall abscess without wounds

A 79-year-old Japanese man presented to our hospital with an 18day history of fever and right-sided chest pain. The patient had undergone surgery for rectal cancer 2 years previously. Although he had three pet cats in his home, he had no history of cat bites, scratches, or licks. On examination, his blood pressure was 92/57 mmHg and temperature was 37.1 °C; a soft subcutaneous mass without obvi...

Characterization of neuraminidases produced by various serotypes of Pasteurella multocida.

Neuraminidases produced by 16 strains of Pasteurella multocida (serotypes 1 to 16) were characterized by molecular weight, substrate specificity, and antigenic identity. After growth in a chemically defined medium, stage I (lyophilized) culture supernatants were assayed for activity with N-acetylneuramin lactose, human alpha-1-acid glycoprotein, fetuin, colominic acid, and bovine submaxillary m...

Pasteurella multocida Toxin Manipulates T Cell Differentiation

Pasteurella multocida causes various diseases in a broad range of wild and domestic animals. Toxigenic strains of the serotypes A and D produce an AB protein toxin named Pasteurella multocida toxin (PMT). PMT constitutively activates the heterotrimeric G protein subunits Gαq, Gα13, and Gαi through deamidation of a glutamine residue, which results in cytoskeletal rearrangements as well as increa...

Pathogenomics of Pasteurella multocida.

The first complete genome sequence of the P. multocida avian isolate Pm70 was reported in 2001. Analysis of the genome identified many predicted virulence genes, including two encoding homologues of the Bordetella pertussis filamentous haemagluttinins, and genes involved in iron transport and metabolism. Availability of the genome sequence allowed for a range of whole-genome trans...

Pasteurella multocida Toxin Activates Various Heterotrimeric G Proteins by Deamidation

Pasteurella multocida produces a 146-kDa protein toxin (Pasteurella multocida toxin, PMT), which stimulates diverse cellular signal transduction pathways by activating heterotrimeric G proteins. PMT deamidates a conserved glutamine residue of the α-subunit of heterotrimeric G proteins that is essential for GTP-hydrolysis, thereby arresting the G protein in the active state. The toxin substrates...